Hypertensive Crisis Associated with Serotonin Syndrome Following Linezolid Administration

Title :
Hypertensive Crisis Associated with Serotonin Syndrome Following Linezolid Administration: Report of Two Cases

Authors:
Foroud Shahbazi, Lida Shojaei

Journal: Current Drug Safety

Year: ۲۰۲۵

:Abstract 
Serotonin syndrome is a potentially life-threatening condition that can occur as a result of the therapeutic use of serotonergic medications or drug interaction. In this study, we describe two cases of serotonin syndrome-associated hypertensive crisis following Linezolid use. The first patient was a 52-year-old female who was admitted due to a diabetic foot infection and pneumonia. Serotonin syndrome occurred 24 hours after starting linezolid. Resistant hypertension was the main hemodynamic finding. Resistant hypertension and other symptoms of serotonin syndrome were resolved about 48 hours after discontinuation of linezolid. The second case was a man with a history of kidney transplant, diabetes, and hypertension. Within 24 hours after fentanyl and linezolid initiation, severe agitation, eye clonus, hyperreflexia, hypertension, and tachycardia were noted. With the possible diagnosis of serotonin syndrome, fentanyl was discontinued, and morphine was initiated. The patient's symptoms improved 48 hours after discontinuation of fentanyl. A thorough evaluation of the patient's medical history can help clinicians prevent this syndrome in critically ill patients  

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fatty liver disease

:Title

The effects of co-administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial

Authors: 

Mohammad Bagher Majnooni, Mari Ataee, Gholamreza Bahrami, Fatemeh Heydarpour, Ina Yosifova Aneva, Mohammad Hosein Farzaei, Touraj Ahmadi-Juobari

Journal: Phytotherapy Research 

Year: 2021

Abstract: 

Medical plants are widely used as a complementary therapy to treat complex diseases, such as nonalcoholic fatty liver disease (NAFLD). Therefore, this study was done to investigate the effect of co-administration of artichoke leaf extract supplement (ALES) with conventional medicines on patients with NAFLD. The clinical trial was based on patients randomly divided into three groups involving metformin-vitamin E (ME), metformin-ALES (MA), and vitamin E-ALES (EA). The effectiveness of treatment in the treated groups was evaluated using liver ultrasonography and biochemical markers. After 12 weeks of treatment, the results showed that the rate of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was significantly reduced within all the study groups (p < .05). Liver ultrasonographic findings revealed that the rate of fat accumulation in liver of patients was decreased significantly within all the study groups and it was increased in the subjects with grade 0 fatty liver (without fat accumulation) in the MA and EA groups by 23.3 and 17.2% respectively. In summary, the results of the present study showed that the concomitant use of ALES with metformin and vitamin E can have beneficial effects on amelioration of complications in patients with NAFLD. However, larger-scale clinical trial studies are required in this regard.  

Antidiabetic Mechanisms of Rosa canina Fruits

Title:

Antidiabetic Mechanisms of Rosa canina Fruits: An In Vitro Evaluation

Authors: 

Ali Fattahi, Fatemeh Niyazi, Behzad Shahbazi, Mohammad Hosein Farzaei, Gholamreza Bahrami

:Journal

Journal of Evidence-Based Complementary & Alternative Medicine

Year: 2017

Abstract: 

Rosa canina fruits have been used traditionally for the treatment of diabetes mellitus and its complications. The aim of current study was to evaluate the in vitro mechanism of action of R canina in managing diabetes mellitus. Cell proliferation and cytotoxicity assay were performed on pancreatic β-cells, βTC6. The protective activity of the extract on streptozotocin-induced death in βTC6 cells was studied. The effect of R canina on the metabolism of glucose in HepG2, a hepatocellular carcinoma cell line, was evaluated. The effect of the extract on glucose diffusion across the dialysis membrane, which is a comfortable model for assessing cellular glucose absorption, was evaluated. The results obtained from current study confirmed that R canina extract can act as a growth factor for pancreatic β-cell line providing a novel mechanism for the observed antidiabetic effect of this natural agent. Further preclinical studies are necessary to evaluate the perfect mechanism of action of R canina in diabetes mellitus.